Different reasons for the formation of different types of proteinuria

Urinary protein is heated by acidification in urine is cloudy and the detection of protein.

24 hours of normal human urine protein ranges ≤ 0.15g, conventional tests negative for urinary protein detection. If detection of urinary protein gravity(25℃) > 150 mg/day, i.e. positive urine protein, human emissions has been a noticeable increase of urinary protein content, belong to abnormal urine protein. Sustained positive urine protein, often on behalf of the kidney lesions occurs, the clinical based how much urine protein-positive to determine the extent of the damage and renal nephropathy treatment effect. Therefore, abnormal urine protein, it is important to effectively control and eliminate, prevent deterioration of progress. According to the causes of urinary protein, can generally be divided into 5 categories:

Glomerular proteinuria

Glomerular proteinuria (glomerularproteinuria) is the result of Glomerular filtration membrane permeabilization of plasma proteins.

Is the most common clinical types. Found in a variety of primary or secondary Glomerulonephritis. Is due to ischemia, poisoning, immune pathology injury destroyed the filtration membrane integrity; or charge owing to filtration membrane barrier effect of weakening.

Renal tubular proteinuria

Under normal circumstances the glomerular filtration of protein and small molecule was practically blocked by renal tubular reabsorption.

When renal tubular disease, protein reabsorption by obstacles, small molecule protein is excreted in urine, including β 2-microglobulin, lysozyme, RNase, etc. As the blood concentration of proteins and small molecules is very low, so the types of patients with urinary protein aggregate less than 2g, sometimes only 10mg or proteinuria exists.

Overflow proteinuria

In some diseases, blood and small molecule-protein concentration increases, such as the two proteins, hemoglobin, Myoglobin, etc.: If the filtrate in a concentration above kidney absorption threshold, it will be possible to discharge, in myeloma, intravascular hemolysis induced diseases.

Secretion of proteinuria

Increased urinary excretion of IgA, in renal tubulointerstitial nephropathy; spinal cord loop segment affected by inflammation Ramus thick and drugs stimulate the secretion of mucus when protein (protein, Tamm Horsfell T-H protein).

Organizational proteinuria

Organizations can be released after the destruction of cytoplasmic proteins in various enzymes and, if the molecular weight, Glomerular filtrate in a concentration exceeding tubular absorption threshold, they can be excreted in the urine.

The protein solution directly from renal tubular discharge, such as the CEA-aFP, lysozyme, tubular basement membrane antigen.

Therefore, the determination of the size and nature of the protein on very meaningful.

SDS-polyacrylamide gel electrophoresis, according to the application of more practical value.

(Edit: internships, Lai-King)