Teach you to understand the hepatitis b surface antigen

Hepatitis b surface antigen discovery

In 1963, Blumbers's in a name for haemophilia and repeatedly received a blood transfusion therapy in patients with a particular antibody is found.

The antibody only and local Australia indigenous serum reacts, thus inferred that serological indigenous Australia has a special type of Antigen material that will turn this antigen material named Australia Antigen, hereinafter referred to as "o-", we said today that the hepatitis b surface antigen.

Relationship with hepatitis b

Experimental studies have shown that the anti-"o" and the incidence of hepatitis b are closely related.

Because it is HBV of coat protein, although not contagious, but it is often accompanied by the presence of HBV, it is the human body is already infected with HBV. "O-" exists in the patient's blood, breast milk, saliva, tears, sweat glands, nasal pharyngeal secretions, semen and vaginal secretions, human infection with the hepatitis b virus 2 ~ 6 months later, when the aminotransferase 2 to 8 weeks before, can be detected in serum positive results. HBsAg-positive duration is generally longer, the individual can take up to 20 years.

October 1976, the World Health Organization (WHO) expert meeting provides for hepatitis b surface antigen (HepatitisBSurfaceAntigen) uniform abbreviated HBAg.

Its molecular weight is 2.4X106, consists of a mix of polypeptide composition, containing lipid, carbohydrate and protein. Its low temperature has strong resistance, inactivation of formaldehyde may cause it to be heated to 60 ° c for 10 hours to reduce their antigenicity, 100 ° c for 5 minutes to completely inactivated.

-Positive significance

HBsAg-positive signs for HBV infection.

If the liver and other HBV infection index are OK but merely HBsAg-positive, and not see any symptoms and signs, it is possible to HBsAg carriers or to have HB, liver function has returned to normal, but has not yet been overcast and HBsAg. Clinical according HBs-Ag titer of low and high estimates of the size of patients with infectious. The higher titer e Antigen (HBeAg), go to oxygen RNA polymerase (DNAP), hepatitis b virus to oxygen acid (HBV-DNA) the likelihood of positive, the stronger the infectious also.

Learn about the "o-" meaning, the aim is to have a correct understanding and attention.

Once found himself as the "o-" positive people, don't panic, but further laboratory tests check to clearly determine the diagnosis, treatment options, and actively cooperate with treatment.

(Edit: internships, Lai-King)