Proteinuria on unknown hazards

Proteinuria on the human body has a lot of harm.

Albuminuria in not just the great loss of nutritional protein, and proteinuria to glomerulus, tubular, etc. will cause damage, resulting in kidney fibrosis. Research has confirmed that the occurrence of proteinuria is the first independent uremia, risk factors, proteinuria is the greatest harm, caused kidney drug erosion of uremia. So what specific proteinuria hazard?

(1) proteinuria mesangial toxicity:

In renal failure model, you can observe the serum protein in Glomerular mesangial accumulation of the macromolecular substances in mesangial area of accumulation can cause mesangial cell damage, hyperplasia of the synthesis of the mesangial matrix, resulting in increased Glomerular sclerosis.

Proteinuria and nephrotic syndrome, Glomerular has low density lipoprotein (LDL) and very low density lipoproteins (VLDL) of apolipoprotein B and apolipoprotein A deposition of these aggregation end can also cause Glomerular sclerosis.

(2) proteinuria on near tubule cells of toxicity:

Proteinuria, renal tubular cells within the protein content increased in the Lysosomal protein activity increase, prompts caused by Lysosomal spilled into the tubular cells pulp, subsequent cell damage can stimulate the formation of inflammation and scarring.

(3) proteinuria caused by changes in cell biology of small tubes:

A lot of proteinuria, renal disease there cell hyperplasia, excessive represents a non-adaptive response, leading to renal failure.

More and more evidence that protein can be directly regulating tubular cells function, change its growth characteristics and Cytokines and the phenotypic expression of matrix protein, can cause small bases bottom side release PDGF, FN and MCP-1, induced fibrosis.

(4) proteinuria caused tubulointerstitial hypoxia increases:

The digestion of proteinuria to absorb large amounts of protein extra energy that may cause the tubule cells hypoxia, resulting tubular cells.

(Edit: internships, Lai-King)