Growth hormone deficiency what checks to determine

GH (growth hormone) lack of

To determine the level of GH, you need to check in a particular situation, and to a number of test combined with the judge, the commonly used test are:

1. go to sleep after blood 30 ~ 60min

In the physiology of GH GH concentration peak detection.

2. gather at night 9 pm to 7: 00 next morning urine

Determination of urinary excretion of GH, there are some reference value, and potentially lower distinguish normal; the practice is still limited, for further observation summary.

3. the arginine irritation test

Intravenous administration of Arginine, after fasting overnight to 0.5g/kg, maximum 20g, to the infusion, 30min test before and after the test, 15, 30, 90 120min blood test GH concentrations.

Normal people affected by this stimulation, 30 ~ 90min GH secretion in increased peak. Pituitary dwarfism GH deficiency without GH release peak or off-peak lower.

4. the levodopa irritation test

Oral levodopa, weight when serving 125mg 15kg, weight at clothing between 15 ~ 35kg 250mg, weight greater than 35kg clothing, medicine and blood 500mg, its clinical significance with arginine stimulation test.

Side effects are mainly nausea gastrointestinal discomfort.

5. clonidine stimulation test

Clonidine orally, 0.10 ~ 0.15mg/m2, blood and its clinical significance and arginine stimulation test.

Note that a small number of patients may appear hypotension and sleepiness.

6. insulin hypoglycaemia test

Hypoglycemia is the human serious stress conditions, the body will release GH.

This experiment has some risk and is not applicable. General employment insulin 0.075 ~ 0.1U/kg, dissolved in normal saline, to finish, injected 2min requests since 20 ~ 40min blood glucose is below 2.5mmol/L (45mg/dl) or up to 50%. Hypoglycemia-General appears after GH increases the peak, at the same time also elevated cortisol. To prevent hypoglycemic coma and convulsions, should open up the intravenous drip, prepare for glucose injection.

The above test is a false positive and false negative, but to insulin hypoglycaemia test at least.

Many other clinically to three test combined with the judgment, if the results remain equivocal, together with hypoglycemia stimulation test. Other there is sugar in the pancreas l, vasopressin, testing, clinical application.

(Edit: internships, Lai-King)